Cancer drug discovery by repurposing: teaching new tricks to old dogs.

Teaching an old dog new tricks: drug repositioning in small cell lung cancer.

Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.

Teaching Old Dogs New Tricks Implementing Organizational Learning in an Asian National Police Force

Colchicine in Acute Myocardial Infarction: “Teaching New Tricks to an Old Dog”

Drug development is often not as linear as one would think. Repurposing of drugs for new uses is now common [1]. This is certainly the case of colchicine. Colchicine is one of the oldest anti-inflammatory drugs [2]. Colchicine was historically used as an unapproved drug to treat Mediterranean fever. In 2009, following compelling evidence in vitro and in vitro of the ability of colchicine to inh...

Perspectives New sources of drugs for hematologic malignancies

Advancing novel therapeutic agents for the treatment of malignancy into the marketplace is an increasingly costly and lengthy process. As such, new strategies for drug discovery are needed. Drug repurposing represents an opportunity to rapidly advance new therapeutic strategies into clinical trials at a relatively low cost. Known on-patent or off-patent drugs with unrecognized anticancer activi...

New sources of drugs for hematologic malignancies.

Advancing novel therapeutic agents for the treatment of malignancy into the marketplace is an increasingly costly and lengthy process. As such, new strategies for drug discovery are needed. Drug repurposing represents an opportunity to rapidly advance new therapeutic strategies into clinical trials at a relatively low cost. Known on-patent or off-patent drugs with unrecognized anticancer activi...